Endometriosis is a painful condition that affects approximately 200 million women worldwide. This occurs when the mucous membrane that normally grows only in the uterus moves outward and attaches, for example, to the surrounding intestine or to the membrane lining the abdominal cavity. This is often accompanied by bleeding, pain and inflammation and can lead to infertility.
In general, it takes about seven years for endometriosis to be detected. Furthermore, it is often initially mistaken for an intestinal disorder. In addition, surgical procedures are often needed to diagnose the disease, and treatments are often inadequate.
Rama Kumagani, professor of pathology and immunology at Baylor College of Medicine (USA), has been researching this condition for years. Through previous research in mice, he and his team determined that the microbiome — the bacteria that live in our bodies — or its metabolites — products produced by bacteria — could contribute to worsening endometriosis.
He snorted
In follow-up research, researchers compared the bacteria and metabolites found in the stool of women with endometriosis with those of healthy women and discovered significant differences, specifically a mix of bacterial metabolites unique to endometriosis.
Women with endometriosis appear to have a lower amount of one of these metabolites, 4-hydroxyindole, than women without the condition. Studies in animal models of the disease show that administration of 4-hydroxyindole prevents the onset and worsening of inflammation and pain.
Researchers are now working to develop a non-invasive stool diagnostic test for endometriosis. They also conduct the necessary studies to ensure safety and effectiveness.
